Tag: Egfp

Glucocorticoid-transactivated TSC22D3 attenuates hypoxia- and diabetes-induced Müller glial galectin-1 expression via HIF-1α destabilization.

Galectin-1/LGALS1, a newly acknowledged angiogenic issue, contributes to the pathogenesis of diabetic retinopathy (DR).Galectin-1/LGALS1, a newly acknowledged angiogenic issue, contributes to the pathogenesis of diabetic retinopathy (DR).

Not too long ago, we demonstrated that glucocorticoids suppressed an interleukin-1β-driven inflammatory pathway for galectin-1 expression in vitro and in vivo. Right here, we present glucocorticoid-mediated inhibitory mechanism in opposition

Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer

Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancerGerminal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer

Hypoxia develops in germinal facilities (GCs) induced by mannequin antigens; nevertheless, it’s unknown whether or not tumor-reactive GCs are additionally hypoxic. We recognized GC hypoxia in lymph nodes (LNs) draining