Within the gastrointestinal tract, interstitial cells of Cajal (ICC) are positioned between nerve fibres and muscle cells and have a task in neuromuscular transmission and muscle contractility. Protein kinase C (PKC) is concerned in modulation of muscle contractility by neurotransmitters, however it’s not identified if PKC has a task in ICC. There are 11 completely different PKC isoforms.
The presence of PKC isoforms in ICC in guinea-pig gastrointestinal tract was examined utilizing fluorescence immunohistochemistry and confocal microscopy. Segments of guinea-pig abdomen, duodenum, ileum, proximal and distal colon have been fastened in zambonis fixative. Frozen sections and wholemounts have been incubated with anti-PKC antibodies (alpha, beta, delta, epsilon, gamma, iota, lambda, mu, theta) adopted by fluorescent secondary antibody.
Solely PKC theta (theta) immunoreactivity was present in ICC. Not one of the different PKC isoforms (alpha, beta, delta, epsilon, gamma, iota, lambda, mu) localized to the ICC. PKC theta immunoreactivity was outstanding in ICC positioned between the round and longitudinal muscle layers (ICC-MY) in all areas besides abdomen and throughout the round muscle (ICC-IM) within the massive gut. PKC theta was not current in ICC within the deep muscular plexus in both duodenum or ileum.
PKC theta immunoreactivity was current within the cell physique and proximal processes of the ICC. The cells containing PKC theta additionally contained cKit confirming the cells have been ICC. ICC-MY within the ileum additionally contained the neurokinin (NK) 1 receptor. In conclusion, PKC theta is current in pacemaker ICC, however its operate is just not but identified. Purposeful research shall be wanted to find out the position of this kinase in ICC.
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Realizing the second messenger cascades and with the ability to manipulate subpopulations of ICC will add to our understanding of the molecular and cell biology of ICC networks throughout the gastrointestinal tract and should finally assist in understanding the aetiology of some gastrointestinal motor pathologies.